The West Virginia Lottery is run by the government of West Virginia. It was established in 1984 via a voter referendum. It is a charter member of the Multi-State Lottery Association (MUSL). The Lottery offers games such as Hot Lotto, Powerball, Mega Millions, and scratch tickets. West Virginia has reinterpreted the amendment to its Constitution that permitted its lottery to include casinos, and thus the West Virginia Lottery Commission also regulates slot machines, which are marketed as "video lottery" and available at several hundred businesses; and five "lottery table games" casinos.

Jack Whittaker, arguably the most notable American lottery winner, won his then-record Powerball jackpot of about $315 million (annuity value) on a ticket bought in West Virginia for the December 25, 2002 drawing.